摘要 |
This invention relates to N-acylamino aryl derivatives of the formula where R<SUP>1</SUP>R<SUP>21</SUP>, R<SUP>22</SUP>, R<SUP>23</SUP>, R<SUP>24</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6</SUP>, R<SUP>7</SUP>, R<SUP>8</SUP>, R, and n are as defined herein and where X is -CHRO, -OCHR-, -CH<SUB>2</SUB>S-, -SCH<SUB>2</SUB>-, -CH<SUB>2</SUB>CH<SUB>2</SUB>-, -CH-CH- or -C≡C-. The compounds of the invention are selective monoamine oxidase B inhibitors, and they are therefore useful in the treatment of diseases mediated by monoamine oxidase B, for example, for the treatment of Alzheimer's disease or senile dementia. |