发明名称 |
METHOD FOR REDUCTION, STABILIZATION AND PREVENTION OF RUPTURE OF LIPID RICH PLAQUE |
摘要 |
<p>There is to provide is an agent for reduction of a lipid rich plaque, stabilization of a lipid rich plaque and/or prevention of rupture of a lipid rich plaque in an atherosclerotic lesion comprising an effective amount of 2-[4-[2-(benzimidazole-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide (hereinafter, referred to as compound 1), its pharmaceutically acceptable salt or a hydrate thereof and Pitavastatin, and a pharmaceutically acceptable carrier, wherein the agent is intended to be simultaneously administered, or separately administered with interval of time to a patient in need thereof. There is also to provide a method for reduction of a lipid rich plaque, stabilization of a lipid rich plaque and/or prevention of rupture of a lipid rich plaque in an atherosclerotic lesion, comprising simultaneously administering, or separately administering with interval of time an effective amount of the compound 1, its pharmaceutically acceptable salt or a hydrate thereof and an effective amount of Pitavastatin to a patient in need thereof.</p> |
申请公布号 |
WO2006064889(A1) |
申请公布日期 |
2006.06.22 |
申请号 |
WO2005JP23088 |
申请日期 |
2005.12.09 |
申请人 |
KOWA CO., LTD.;KOBAYASHI, HIDEYUKI;YOSHINAKA, YASUNOBU;SHIBUYA, KIMIYUKI |
发明人 |
KOBAYASHI, HIDEYUKI;YOSHINAKA, YASUNOBU;SHIBUYA, KIMIYUKI |
分类号 |
A61K31/497;A61K31/47;A61P9/10 |
主分类号 |
A61K31/497 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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