CYTOTOXIC ANTIBODY DIRECTED AGAINST TYPE B LYMPHOID HEMATOPOIETIC PROLIFERATIONS
摘要
The invention concerns a monoclonal antibody directed against the CD20 antigen, whereof the variable region of each of the light chains is encoded by a sequence having at least 70 % identity with the murine nucleic acid sequence SEQ ID NO: 5, the variable region of each of the heavy chains is encoded by a sequence having at least 70 % identity with the murine nucleic acid sequence SEQ ID NO: 7 and the constant regions of light chains and of heavy chains are constant regions derived from a non-murine species. The invention also concerns the use of said antibody to activate Fc?RIII receptors of immune effector cells, and for making a drug, in particular for treating leukemia or a lymphoma.
申请公布号
WO2006064121(A2)
申请公布日期
2006.06.22
申请号
WO2005FR03123
申请日期
2005.12.14
申请人
LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES;DE ROMEUF, CHRISTOPHE;GAUCHER, CHRISTINE;TEILLAUD, JEAN-LUC;PROST, JEAN-FRANCOIS
发明人
DE ROMEUF, CHRISTOPHE;GAUCHER, CHRISTINE;TEILLAUD, JEAN-LUC;PROST, JEAN-FRANCOIS