| 摘要 |
The formulation and method of producing a directly compressible pharmaceutical composition that has metformin as an active ingredient. To produce the pharmaceutical composition, a binding solution of povidone, starch and water is created. The binding solution is then mixed with a high concentration of metformin HCl to form a first mix composition. The first mix composition is dried. The dried first mix composition is then milled into granules. Various dry lubricants can be blended with the granules if desired. The result is a bulk pharmaceutical composition in which metformin HCl is the active ingredient and is present in a concentration of over 90% by weight. Yet, the bulk pharmaceutical composition exists as a free flowing powder that can be directly compressed into tablets and is chemically stable during periods of long storage.
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