1,5-Diaryl-pyrrole-3-carboxamide derivatives and their use as cannabinoid receptor modulators

摘要

The present invention relates to a compound of formula (I) in which R¹ and R² independently represent phenyl, thienyl or pyridyl each of which is optionally substituted by one, two or three groups represented by Z; and R³ is H, a C_1-3alkyl group, a C_1-3alkoxymethyl group, trifluoromethyl, a hydroxyC_1-3alkyl group, an aminoC_1-3alkyl group, C_1-3alkoxycarbonyl, carboxy, cyano, carbamoyl, mono or di C_1-3alkylcarbamoyl, acetyl, or hydrazinocarbonyl of formula -CONHNR^aR^b wherein R^a and R^b are as defined for R⁴ and R⁵ respectively; X is CO or SO₂; Y is absent or represents NH optionally substituted by a C_1-3alkyl group; R⁴ and R⁵ independently represent: a C_1-6alkyl group; an (amino)C_1-4alkyl-group in which the amino is optionally substituted by one or more C_1-3alkyl groups; an optionally substituted non-aromatic C_3-15carbocyclic group; a (C_3-12cycloalkyl)C_1-3alkyl-group; a group -(CH₂)_r(phenyl)_s; naphthyl; anthracenyl; a saturated 5 to 8 membered heterocyclic group containing one nitrogen and optionally one of the following: oxygen, sulphur or an additional nitrogen wherein the heterocyclic group is optionally substituted; 1-adamantylmethyl; a group -(CH₂)_t Het where Het represents an aromatic heterocycle optionally substituted; or R⁴ represents H and R⁵ is as defined above; or R⁴ and R⁵ together with the nitrogen atom to which they are attached represent a saturated 5 to 8 membered heterocyclic group; R⁶ is H, a C_1-3alkyl group, a C_1-3alkoxymethyl group, trifluoromethyl, a hydroxyC_1-3alkyl group, C_1-3alkoxycarbonyl, carboxy, cyano, carbamoyl, mono or di C_1-3alkylcarbamoyl, acetyl, or hydrazinocarbonyl of formula -CONHNR^aR^b; with provisos; to processes for preparing such compounds, to their use in the treatment of obesity, psychiatric and neurological disorders particularly obesity, to methods for their therapeutic use and to pharmaceutical compositions containing them.