DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH LEUCINE-RICH REPEAT-CONTAINING GPCR 6 (LGR6)

摘要

The invention provides a human LGR6 which is associated with the cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, hematological disorders, respiratory diseases, inflammatory diseases, neurological disorders, reproduction disorders, cancer disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, hematological disorders, respiratory diseases, inflammatory diseases, neurological disorders, reproduction disorders, cancer disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of LGR6 as well as pharmaceutical compositions comprising such compounds.