1,2,3-TRIAZOLE AND IMIDAZOLE COMPOUNDS AND THEIR ANTITUMOR USE

摘要

A discovery underlying this invention is the concordance between particul ar cellular signaling mechanisms and cancer cell growth and metastasis. It has now been discovered that the compounds <IMG> inhibit the signal transduction required for the maintenance and driving of the malignant process. These compounds are also effective for the in vivo treatment of solid tumors and related disease states. This invention provides uses for the compounds to inhibit invasion and metastasis of solid tumors, and for the treatment of diseases involving aberrant signal transduction pathways.