COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF INSULIN RESISTANCE
摘要
Disclosed herein are methods of delaying the onset or treating diabetes that comprises administering a uric acid lowering agent. The inventors have made the remarkable discovery that elevated uric acid levels are not a corollary to insulin resistance, but rather a primary mediator of insulin resistance. Specifically exemplified are methods that involve administering to a patient susceptible to development of diabetes a composition comprising a uric acid lowering agent in a regimen that maintains serum uric acid levels below at least 5.2 to 5.5 mg/dl.
申请公布号
WO2006012438(A3)
申请公布日期
2006.05.18
申请号
WO2005US25910
申请日期
2005.07.21
申请人
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.;JOHNSON, RICHARD, J.;NAKAGAWA, TAKAHIKO