发明名称 |
METHOD OF IDENTIFYING COMPOUNDS FOR BACTERIAL GROWTH MODULATION |
摘要 |
<p>The present invention relates to a method of identifying a candidate compound for modulating bacterial growth. This the method involves providing a ß clamp peptide from a bacterial replicase, providing a second peptide that binds to at least one amino acid of SEQ ID NO:9 that is not designated X, wherein the second peptide does not exhibit polymerase activity, and providing a test compound. The ß clamp peptide and the second peptide are contacted with the test compound, and the level of binding between the ß clamp peptide and the second peptide in the presence of the test compound is determined. The level of binding between the ß clamp peptide and the second peptide in the presence of the test compound is then compared to a control that does not contain the test compound. A test compound that alters the level of binding between the ß clamp peptide and the second peptide compared to the control is a candidate compound for modulating bacterial growth.</p> |
申请公布号 |
WO2006052746(A2) |
申请公布日期 |
2006.05.18 |
申请号 |
WO2005US39997 |
申请日期 |
2005.11.03 |
申请人 |
THE ROCKEFELLER UNIVERSITY;O'DONNELL, MICHAEL, E.;GEORGESCU, ROXANA |
发明人 |
O'DONNELL, MICHAEL, E.;GEORGESCU, ROXANA |
分类号 |
C12Q1/18 |
主分类号 |
C12Q1/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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