| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing clopidogrel, capable of industrially suitably producing the clopidogrel at a low cost in a good yield. SOLUTION: In this method, a compound expressed by formula (II) [X is a halogen or a group expressed by R'SO<SB>3</SB>(R' is a lower alkyl which may be halogenated or an aryl which may be substituted); and R is a substituent which has an asymmetric carbon] and a compound expressed by formula (III) are together reacted, preferably, in the presence of a phase transfer catalyst, so that a compound expressed by formula (IV) is produced, while the reaction is diastereoselectively progressed by being accompanied with epimerization of a substituent X, and further the produced compound is converted into the clopidogrel. COPYRIGHT: (C)2006,JPO&NCIPI
|
