FORMATION OF NOVEL ERYTHROPOIETIN CONJUGATES USING TRANSGLUTAMINASE.

摘要

The invention provides biologically active erythropoietin (EPO) conjugate compositions wherein a transglutaminase reaction is employed to covalently and site specifically conjugate the EPO molecule to a non-antigenic hydrophilic polymer that can also be covalently linked to an organic molecule either of which modification increases the circulating serum half-life of the composition.