| 摘要 |
<p>The invention relates to medicine. The inventive sedative and spasmolytic medicinal agent comprises an a bromomethyl butanoic acid ethyl ether, phenobarbital, brandy mint oil, microcrystalline cellulose and adjuvants for forming solid dosage form (pills) which are coated with a shell containing ß cyclodextrine or the derivatives thereof. The first variant of a method for producing said medicinal agent consists in mixing the a bromomethyl butanoic acid ethyl ether with the brandy mint oil, wherein the quantity of said mixture is equal to 4.5 % of the total pill mass, in adding said mixture into the humidified ß cyclodextrine, stirring for 1-2 minutes, drying, granulating, in mixing the granulate with the phenobarbital, microcrystalline cellulose and adjuvant powders, in pressing a pill and in coating said pill with the ß cyclodextrine-containing shell. The second variant of said method consists in mixing the phenobarbital with the adjuvant-filler, in separately preparing the mixture of the a bromo-methyl butanoic acid ethyl ether and the brandy mint oil, in adding the microcrystalline cellulose, developed crystal face powders, openers and sliding agents, in adding said mixture into the phenobarbital-filler mixture, in pressing a pill and in coating said pill with the ß cyclodextrine-containing shell.</p> |
