发明名称 |
Compositions and methods for activating toll-like receptor 4 |
摘要 |
Methods for activating Toll-like receptor 4 via cholesterol-dependent cytolysins isolated from a Gram-positive bacteria are provided. In addition compositions containing an isolated cholesterol-dependent cytolysin or a fragment thereof or a mimetic of the cytolysin or fragment thereof and methods for use of such composition in inhibiting binding and/or interaction of Toll-like receptor 4 with endotoxin are provided. Methods for identifying modulators of Toll-like receptor 4 activation by a cholesterol-dependent cytolysin and use of such modulators in treatment of septicemia and/or septic shock are also provided.
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申请公布号 |
US2006089305(A1) |
申请公布日期 |
2006.04.27 |
申请号 |
US20050248085 |
申请日期 |
2005.10.12 |
申请人 |
REST RICHARD;KARIN MICHAEL;PARK JIN M |
发明人 |
REST RICHARD;KARIN MICHAEL;PARK JIN M. |
分类号 |
A61K38/16;A61K38/17 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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