发明名称 |
PYRUVATE DEHYDROGENASE KINASES AS THERAPEUTIC TARGETS FOR CANCER AND ISCHEMIC DISEASES |
摘要 |
<p>The invention provides therapeutic and prophylactic compounds and methods for altering the activity of pyruvate dehydrogenase kinase (e.g. PDK1, PDK2, PDK3, PDK4). Such therapies are useful for the treatment of neoplasia. The invention further provides therapeutic and prophylactic compounds and methods of altering pyruvate dehydrogenase activity to treat or prevent cell death related to ischemia.</p> |
申请公布号 |
CA2584057(A1) |
申请公布日期 |
2006.04.20 |
申请号 |
CA20052584057 |
申请日期 |
2005.10.06 |
申请人 |
THE JOHNS-HOPKINS UNIVERSITY |
发明人 |
KIM, JUNG-WHAN;DANG, CHI V.;SEMENZA, GREGG |
分类号 |
A61K39/395;C12N15/113 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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