<p>A cerebral infarction suppressant that is effective against brain tissue necrosis after long-time ischemia occurring in actual cerebral infarction, having reduced side effects. There is provided a suppressant for cerebral infarction due to long-time ischemia, characterized by containing as active ingredients histidine and an H<SUB>3</SUB> receptor blocker, or histidine and a histamine N-methyltransferase inhibitor.</p>
