H1yA-peptide or its derivative, its variant or its fragment used in pharmaceutical composition and medicine for treating disease e.g. sepsis caused by RTX bacterial toxins, has amino acids

摘要

H1yA-peptide or its derivative, its variant or its fragment, has 23 amino acids (SEQ ID NO: 1), given in the specification. Pharmaceutically acceptable salt is also present in H1yA-peptide derivative. Independent claims are included for the following: (1) EhxA-peptide or its derivative, its variant or its fragment, which has 23 amino acids (SEQ ID NO: 2), given in the specification; (2) ApxIIIa-peptide or its derivative, its variant or its fragment, which has 21 amino acids (SEQ ID NO: 3), given in the specification; (3) ApxIa-peptide or its derivative, its variant or its fragment, which has 38 amino acids (SEQ ID NO: 4), given in the specification; (4) LktA-peptide or its derivative, its variant or its fragment, which has 32 amino acids (SEQ ID NO: 5), given in the specification; (5) AshA-peptide or its derivative, its variant or its fragment, which has 32 amino acids (SEQ ID NO: 6), given in the specification; (6) Akta-peptide or its derivative, its variant or its fragment, which has 31 amino acids (SEQ ID NO: 7), given in the specification; (7) CyaA-peptide or its derivative, its variant or its fragment, which has 27 amino acids (SEQ ID NO: 8), given in the specification; (8) an isolated DNA sequence with 63-111 nucleobases (SEQ ID NOs: 9-16), given in the specification; (9) a nucleic acid construct, which comprises a promoter that is linked to the isolated DNA sequence; (10) an expression vector, which comprises isolated DNA sequence; (11) an expression system for transforming prokaryotic or eukaryotic cells, which comprises nucleic acid construct and expression vector; (12) a transformed organism, which comprises isolated DNA sequence; and (13) a method for producing a peptide, which involves transforming an organism with a nucleic acid construct and permitting the expression of the peptide and then isolating and purifying peptide. ACTIVITY : Antibacterial; Immunosuppressive; Antiinflammatory; Neuroprotective; Nephrotropic; Uropathic; Antidiarrheic. No biological data given. MECHANISM OF ACTION : None given.