| 摘要 |
<p>D-type cyclin including D1, D2 and D3 are shown to be actively involved in the regulation of cardiomyocyte cell growth and proliferation. The levels of the various cyclins including the relative levels of these three cyclins have varying effects on the growth of cardiomyocytes. Type-D cyclin levels vary with response to various stimuli including injury effects D-type cyclin levels and localization within cardiomyocytes. Various methods, materials and systems for screening for candidate molecules that may effect D-type cyclin levels including molecules that may affect the expression, stability and/or subcellular location or other aspects of one or more of the cyclin D proteins are described. Various types of molecules including RNAi, small molecules, proteins, nucleic acids, and the like can be screened to identify candidate molecules.</p> |
