BIARYL DERIVATIVE

摘要

Disclosed are a compound represented by the formula (I) below, a pharmaceutically acceptable salt thereof, a solvate of those, and a pharmaceutical composition containing such a compound. (In the formula, X<SUP>1</SUP> represents N or CR<SUP>2</SUP>; X<SUP>2</SUP> represents N or CR<SUP>4</SUP>; R<SUP>1</SUP>-R<SUP>6</SUP> independently represent a hydrogen, a halogen, a lower alkyl, a lower alkoxy or the like; the dotted line represents a single bond, a double bond or the like; Y represents COOR<SUP>A</SUP>, CONR<SUP>B</SUP>(CR<SUP>C</SUP>R<SUP>D</SUP>)<SUB>p</SUB>COOR<SUP>A</SUP>, CONR<SUP>E</SUP>R<SUP>F</SUP>, CONR<SUP>B</SUP>(CR<SUP>C</SUP>R<SUP>D</SUP>)<SUB>p</SUB>CONR<SUP>E</SUP>R<SUP>F</SUP> or the like; R<SUP>A</SUP>-R<SUP>F</SUP>, R<SUP>H</SUP> and R<SUP>J</SUP> independently represent a hydrogen, a lower alkyl or the like; R<SUP>G</SUP> represents a lower alkyl, an aryl, a heterocycle or the like; p represents 1 or 2; ring A represents an optionally substituted phenyl or indolyl, or the like; X<SUP>3</SUP> represents O, S or NR<SUP>13</SUP>; X<SUP>4</SUP> represents CR<SUP>7</SUP> or N; X<SUP>5</SUP> represents CR<SUP>8</SUP> or N; X<SUP>6</SUP> represents CR<SUP>9</SUP> or N; X<SUP>7</SUP> represents CR<SUP>10</SUP> or N; R<SUP>7</SUP>-R<SUP>12</SUP> independently represent a hydrogen, a halogen, a lower alkyl or the like; R<SUP>13</SUP> and R<SUP>14</SUP> independently represent a hydrogen, a lower alkyl or the like; W represents a hydrogen, a lower alkyl, NR<SUP>15</SUP>R<SUP>16</SUP> or the like; and R<SUP>15</SUP>-R<SUP>21</SUP> independently represent a hydrogen, a lower alkyl or the like.)