DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH MATRIX METALLOPROTEINASE 9 (MMP9)

摘要

The invention provides a human MMP9 which is associated with the infections, cardiovacular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases, urological diseases, reproduction diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of infections, cardiovacular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases, urological diseases, reproduction diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of MMP9 as well as pharmaceutical compositions comprising such compounds.