OPTICAL FIBER ARRAY BIOCHIP BASED ON WHITE-LIGHT REFLECTROMETRIC INTERFERENCE SPECTROSCOPY

摘要

The invention discloses a kind of optical fiber micro-fluidic biochip that is used to detect the existence and/or density change of certain biological or chemical materials. This bio-chip employs optical fibers as sensors. One or multiple layers of materials are immobilized at one end surface of the fiber, where the immobilized materials are of different properties both from the fiber and from the materials to be detected. At least one of the immobilized layers is made of such a material that is complementary to the biological or chemical material to be detected. When molecules of the biological or chemical material bind onto the complementary material layer, spectral interference distribution patterns of light beams reflected from the fiber-tip layers are shifted. This kind of spectrum shift is then used to, quantitatively or qualitatively, analyze the density, binding speed, as well as geometry of the sample molecules. By adding many fibers into a linear array or a two-dimensional array and using an N:1 optical fiber coupler, a device can be built that is capable of detecting multiple properties of a single sample (analyte) or multiple properties of multiple samples (analytes).