摘要 |
The present invention refers to isoxazole derivatives, in particular 3,4-diaryl isoxazole derivatives, to their pharmaceutical compositions, the process for preparing them and their use as inhibitors of cycloosygenase, in particular of cycloosygenase 1 and 2 (COX-1) (COX-2). The present invention also refers to a process for determining the potential toxicity of compounds that inhibit cycloosygenase (COX), in particular cycloosygenase-2 (COX-2) isoform, and to the use of compounds that inhibit cycloosygenase (COX), in particular cycloosygenase-2 (COX-2) and their pharmaceutical compositions, in subjects for whom the potential cardiovascular toxicity of said compounds is reduced. |
申请人 |
UNIVERSITA DEGLI STUDI DI BARI;UNIVERSITA' DEGLI STUDI DI CHIETI;SCILIMATI, ANTONIO;DI NUNNO, LEONARDO;VITALE, PAOLA;PATRIGNANI, PAOLA;TACCONELLI, STEFANIA;PORRECA, ETTORE;STUPPIA, LIBORIO |
发明人 |
SCILIMATI, ANTONIO;DI NUNNO, LEONARDO;VITALE, PAOLA;PATRIGNANI, PAOLA;TACCONELLI, STEFANIA;PORRECA, ETTORE;STUPPIA, LIBORIO |