发明名称 |
THERAPEUTIC COMBINATIONS COMPRISING POLY(ADP-RIBOSE) POLYMERASES INHIBITOR |
摘要 |
<p>This invention generally relates to use of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by formula 1 as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. This invention provides pharmaceutical combinations of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of using such combinations to treat subjects suffering from diseases such as cancer.</p> |
申请公布号 |
CA2581200(A1) |
申请公布日期 |
2006.03.30 |
申请号 |
CA20052581200 |
申请日期 |
2005.09.09 |
申请人 |
CANCER RESEARCH TECHNOLOGY LTD;PFIZER LIMITED |
发明人 |
JONES, CHRISTOPHER;KAUFMAN, RHONDA;CURTIN, NICOLA JANE;NEWELL, DAVID RICHARD;BORITZKI, THEODORE JAMES;STEINFELDT, HEIDI MARIE;STRATFORD, IAN J.;THOMAS, HUW DAVID;HOSTOMSKY, ZDENEK;PLUMMER, ELIZABETH RUTH;REICH, STEVEN DAVID;WILLIAMS, KAYE JANINE;KLAMERUS, KAREN J.;CALVERT, ALAN HILARY;DEWJI, MOHAMED RAZA |
分类号 |
A61K31/55;A61K31/282;A61K31/4188;A61K31/4745;A61K31/513;A61K31/519;A61K31/704;A61K33/24;A61P35/00 |
主分类号 |
A61K31/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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