发明名称 |
PROCESS FOR PREPARING CYCLOHEXANEDIACETIC ACID MONOAMIDE |
摘要 |
A new process is described for synthesising cyclohexanediacetic acid monoamide, a key compound in the synthesis of grabapentin precursors. The process of the invention is characterised by reacting cyclohexanone with cynoacetamide and immediately after, with a suitable malonic acid ester. A new intermediate (5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylic acid ester) is obtained which is convertible, under mild reaction conditions, into cyclohexanediacetic acid monoamide. |
申请公布号 |
WO2005090310(A3) |
申请公布日期 |
2006.03.16 |
申请号 |
WO2005EP51243 |
申请日期 |
2005.03.17 |
申请人 |
CAFFARO S.R.L.;DANIELI, BRUNO;DELOGU, PIETRO;DE ROSA, SABRINA;FUGAZZA, LORENZA |
发明人 |
DANIELI, BRUNO;DELOGU, PIETRO;DE ROSA, SABRINA;FUGAZZA, LORENZA |
分类号 |
C07D221/20 |
主分类号 |
C07D221/20 |
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