A conjugate formed in vivo and comprised of endogenous albumin and an amine-containing compound, such as a protein or a drug, is described. The conjugate is formed by in vivo cleavage of a polymer-dithiobenzyl-therapeutic agent conjugate to form an albumin-dithiobenzyl-therapeutic agent conjugate. The dithiol moiety of the albumin-therapeutic agent conjugate is cleaved in vivo to yield the free therapeutic agent in native form.
申请公布号
WO2006029150(A2)
申请公布日期
2006.03.16
申请号
WO2005US31705
申请日期
2005.08.31
申请人
ALZA CORPORATION;HUTCHINS, MARIA, U.;KIWAN, RADWAN;ZALIPSKY, SAMUEL
发明人
HUTCHINS, MARIA, U.;KIWAN, RADWAN;ZALIPSKY, SAMUEL