SUBSTITUTED BIPHENYL DERIVATIVE

摘要

A biaryl derivative having excellent collagen synthesis inhibitory activity or a pharmacologically acceptable salt thereof. The biaryl derivative is represented by the general formula 1 [wherein R<SUP>1</SUP> is, e.g., C<SUB>6-10</SUB> aryl substituted by one to three substituents independently selected from the group consisting of a group represented by R-L-, di(C<SUB>1-6</SUB> alkyl)amino, di(C<SUB>1-6</SUB> alkyl)aminosulfonyl, hydroxyaminocarbonyl, and halogeno; R is C<SUB>1-6</SUB> alkyl, etc.; L is sulfonyl, aminosulfonyl, sulfonylamino, etc.; R<SUP>2</SUP> is hydrogen, etc.; A is a group represented by the formula (II), (III), or (IV); R<SUP>3</SUP> is C<SUB>1-6</SUB> alkyl, etc.; and R<SUP>4</SUP> is C<SUB>1-6</SUB> alkyl, etc.].