发明名称 |
Process and intermediates for the selective synthesis of Fluvastatin |
摘要 |
<p>The invention relates to process for the selective preparation of 3-hydroxy-6-dialkoxyphosphoryl-5-oxo-hexanoic acid esters, comprising a first step, in which a methylphosphonic acid dialkylester is treated with a base, and a second step, in which the product of the primary reaction is reacted with an optionally 3-protected 3-hydroxy-1,5-pentanoic diacid ester.</p> |
申请公布号 |
EP1634870(A1) |
申请公布日期 |
2006.03.15 |
申请号 |
EP20040020350 |
申请日期 |
2004.08.27 |
申请人 |
ZHEJIANG HISUN PHARMACEUTICAL CO. LTD.;TIEFENBACHER PHARMACHEMIKALIEN ALFRED E.TIEFENBACHER GMBH & CO.KG |
发明人 |
GUORONG, ZHU;HONGQUAN, GONG;BECKER, STEFAN, DR. |
分类号 |
C07D209/24;A61K31/405;C07F9/40 |
主分类号 |
C07D209/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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