| 发明名称 |
CULTIVATION OF LAWSONIA INTRACELLULARIS, ANTI-LAWSONIA INTRACELLULARIS VACCINE AND DIAGNOSTIC AGENT |
| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a method for large scale cultivation of Lawsonia intracellularis, and a non-toxic attenuated strain and a method for producing the same, and further a method for detecting an antibody against Lawsonia intracellularis using the obtained cultured cells, and a vaccine. <P>SOLUTION: In the cultivation, cultured cells are inoculated with the Lawsonia intracellularis bacteria, and incubated in a reduced oxygen concentration and the infected cells are maintained in suspension to culture the cells. The attenuated Lawsonia intracellularis strain is also obtained by subcultivation of the infected cultured cells. <P>COPYRIGHT: (C)2006,JPO&NCIPI</p> |
| 申请公布号 |
JP2006061165(A) |
申请公布日期 |
2006.03.09 |
| 申请号 |
JP20050304585 |
申请日期 |
2005.10.19 |
| 申请人 |
BOEHRINGER INGELHEIM NOBL LAB INC |
发明人 |
KNITTEL JEFFREY P;ROOF MICHAEL B |
| 分类号 |
C12N1/20;G01N33/554;A61K39/02;A61K39/07;A61K39/106;A61K39/40;A61P1/00;A61P31/04;C07K16/12;C12N1/00;C12N1/36;C12N5/06;C12N9/92;C12Q1/02;G01N33/53;G01N33/569 |
主分类号 |
C12N1/20 |
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