发明名称 |
MRI contrast agent for visualization of plaque, lymph nodes, infarcted and necrotic tissue or both necrosis and tumors, comprising perfluoroalkylated metal complex having specific micelle forming properties |
摘要 |
Use of perfluoroalkylated metal complexes (I), having a critical micelle formation concentration of less than 1 mM, a hydrodynamic micelle diameter of more than 1 nm and a proton relaxivity in plasma of more than 10 l/mmol.s is claimed as magnetic resonance imaging (MRI) contrast agent for visualization of e.g. plaque, lymph nodes or infarcted and necrotic tissue. - The use of perfluoroalkylated metal complexes (I), having a critical micelle formation concentration of less than 1 (preferably less than 0.1) mM, a hydrodynamic micelle diameter ( 2 Rh) of more than 1 (preferably more than 4) nm and a proton relaxivity in plasma (R1) of more than 10 (preferably more than 15) l/mmol.s is claimed as magnetic resonance imaging (MRI) contrast agent for visualization of plaque, lymph nodes or infarcted and necrotic tissue or for independent visualization of necrosis and tumors.
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申请公布号 |
DE10040380(B4) |
申请公布日期 |
2006.03.09 |
申请号 |
DE2000140380 |
申请日期 |
2000.08.11 |
申请人 |
SCHERING AG |
发明人 |
NIEDBALLA, ULRICH;MISSELWITZ, BERND;PLATZEK, JOHANNES;MARESKI, PETER;WEINMANN, HANS-JOACHIM;RADUECHEL, BERND |
分类号 |
A61K49/10;C07F3/00;C07H15/04;C07K5/06 |
主分类号 |
A61K49/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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