| 摘要 |
<p>It is intended to provide a nucleic acid having such an activity as being available as a target of retrovirus integration; an antiviral agent containing this nucleic acid; a vector containing this nucleic acid; a method of treating a retroviral disease; and a method of conveniently and highly reproducibly testing the activity as a target of retrovirus integration. Namely, a nucleic acid which has a substantially palindromic sequence comprising a motif sequence:5'-a<SUB>1</SUB>-a<SUB>2</SUB>- · · · -a<SUB>n</SUB>-X-ß<SUB>n</SUB>- · · · -ß<SUB>2</SUB>-ß<SUB>1</SUB>-3' (wherein a<SUB>1</SUB> to a<SUB>n</SUB> represent each a sequence consisting of 4 to 7 consecutive bases in a sequence 5'-CACAGTG-3' or 5'-CACTGTG-3'; X represents an arbitrary sequence consisting of 0 to 10 bases; ß<SUB>1</SUB> to ß<SUB>n</SUB> represent each a sequence consisting of 4 to 7 bases and being substantially complementary in the reverse direction to one of the above-described sequences a<SUB>1</SUB> to a<SUB>n</SUB>; and n is an integer of 1 or above, provided that an arbitrary sequence consisting of from one to several bases may be sandwiched between each adjacent sequences in a<SUB>1</SUB> to a<SUB>n</SUB> and ß<SUB>1</SUB> to ß<SUB>n</SUB>), an upstream sequence adjacent thereto and a downstream sequence adjacent thereto, and has an activity as a target of retrovirus integration.</p> |
