| 摘要 |
The dihydrogenphosphate salt of 4-oxo-4 -[3-(trifluoromethyl)-5, 6-dihydro [1, 2, 4]triazolo[4, 3-a]pyrazin- 7(8H)-yl]-1-(2, 4, 5-trifluorophenyl) butan-2 -amine is a potent inhibitor of dipeptidyl peptidase-IV and is useful for the prevention and/or treatment of non-insulin dependent diabetes mellitus, also referred to as type 2 diabetes. The invention also relates to a crystalline monohydrate of the dihydrogenphosphate salt as well as a process for its preparation, pharmaceutical compositions containing this novel form and methods of use for the treatment of diabetes, obesity, and high blood pressure. |
