NONHUMAN ANIMAL WITH INHIBITED GdsmA GENE FUNCTION AND PROMOTED OR INHIBITIED CANCERATION-ASSOCIATED GENE FUNCTION

摘要

By transferring Trp53(p53) knockout allele into Rim3 having a mutation in GsdmA3, Rim3 hetero p53 knockout hetero individuals (GsdmA3<SUP>Rim3</SUP>/+;Trp53<SUP>-</SUP>/+) are constructed. As a result, these individuals spontaneously suffer from multiple skin squamous carcinoma from 7 months after birth. The onset of similar skin squamous carcinoma is observed in more than 80% of the individuals 12 months after birth. It is further observed that these cancer cells spread to lymph nodes.