发明名称 Amphiphilic compounds and vesicles liposomes for organ-specified drug targeting
摘要 An amphiphilic compound is provided capable of forming vesicles or liposomes, said amphiphilic compound having at least one headgroup containing a selectively cleavable group or moiety such as a residue of a choline or phenylalanine derivative, and at least one hydrogen-bonding group located either within said headgroup and/or in close proximity thereto. The cleavable group or moiety is cleaved under selective conditions including change of chemical, physical or biological environment and is preferably cleaved enzymatically in a biological environment such as the brain or the blood. Vesicles or liposomes made from said amphiphilic compounds are suitable for delivery of a therapeutic substance or a diagnostic agent specifically to a target organ or tissue, or for delivery of a nucleic acid for gene therapy.
申请公布号 US2006039962(A1) 申请公布日期 2006.02.23
申请号 US20050497705 申请日期 2005.02.07
申请人 BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY 发明人 HELDMAN ELIAHU;LINDER CHARLES;GRINBERG SARINA
分类号 A61K9/127;A61K31/137;A61K31/197;A61K31/198;A61K31/27;A61K31/4425;A61K31/473;A61K31/704;A61K38/00;A61K38/28;A61K39/395;A61K45/00;A61K47/16;A61K47/18;A61K47/22;A61K47/28;A61K47/42;A61K48/00;A61K49/00;A61P3/10;A61P25/16;A61P25/28;A61P29/00;C07C219/06;C07C229/12;C07C233/36;C07C235/28;C07C237/10;C07C237/12;C07D303/46;C07D401/04;C07H7/00;C07H15/26 主分类号 A61K9/127
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