AMINOTHIAZOLES AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS

摘要

Compounds of formula (I) in free or salt form, where A is a C₆-C₁₅ monovalent aromatic group. R¹ is hydrogen, phenyl optionally substituted by one or more substituents selected from halogen, cyano, hydroxy, C₁-C₈-alkyl, C₁-C₈-haloalkyl, C₁-C₈-alkoxy, C₁-C₈-alkoxy-C₁-C₈-alkyl or acyloxy, or a 5- or 6-membered monovalent heterocyclic group, R² is hydrogen, C₁-C₈-alkyl, acyl or CON(R³)R⁴, provided that R² is C₁-C₈-alkyl, acyl or CON(R³)R⁴ when R¹ is hydrogen, R³ and R⁴ are each independently hydrogen, or C₁-C₈-alkyl, together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, and Z^l, Z², Z³ and Z⁴ are each independently N or CR⁵, at least one of them being CR⁵, and R⁵ is hydrogen, C₁-C₈-alkyl or C₁-C₈-alkoxy. The compounds are useful as adenosine receptor antagonists, particularly in the treatment of inflammatory or obstrucive airways diseases