METHOD AND OBTAINED HUMAN ANTIBODY OR ITS ANTIGEN-BINDING FRAGMENT FOR INHIBITING HUMAN TNFalpha ACTIVITY, APPLYING THE OBTAINED HUMAN ANTIBODY OR ITS ANTIGEN-BINDING FRAGMENT AS INGREDIENT FOR PRODUCING MEDICAMENT

摘要

FIELD: medicine. ^ SUBSTANCE: obtained human antibody or its antigen-binding fragment specifically binds tumor necrosis factor hTNFalpha. The like antibodies show high affinity relative to hTNFalpha in vitro and in vivo. Antibodies according to the invention are taken as a full-length antibody or its antigen-binding fragment. The antibodies or their fragments are usable for detecting hTNFalpha and for inhibiting hTNFalpha activity in human beings suffering from a disorder in the case of which hTNFalpha activity is harmful. ^ EFFECT: wide range of applications of high affinity recombinant antibodies to hTNFalpha or their fragments of low dissociation kinetics. ^ 15 cl, 11 dwg, 17 tbl