RECOMBINANT HUMAN SERUM ALBUMIN-METALLIC PHORPHYRIN COMPLEX, ARTIFICIAL OXYGEN CARRIER AND ERYTHROCYTE SUBSTITUTE

摘要

A recombinant human serum albumin-metallic porphyrin complex wherein a metallic porphyrin is bonded, via a coordinate bond, to a recombinant human serum albumin having at least one histidine residue capable of binding to the 5-coordination site of metallic porphyrin, which has been transferred into the sub domain IB (a hem binding site) of human serum albumin by a gene recombination technique, and having a substitution of tyrosine at the 161-position by a hydrophobic amino acid other than tyrosine.