发明名称 |
Neue 1-(1-(Hetero)aryl-1-perhydroxyalkylmethyl)-Piperazinverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
摘要 |
1-(1-(Hetero)aryl)-1-(polyhydroxyalkyl)-methyl)-4-(4-(N-methylbenzamid o)-3-phenylbutyl)-piperazine derivatives (I) are new. Also new are 1-unsubstituted analog intermediates (II). 1-(1-(Hetero)aryl)-1-(polyhydroxyalkyl)-methyl)-4-(4-(N-methylbenzamid o)-3-phenylbutyl)-piperazine derivatives of formula (I) and their acid addition salts are new. A = naphthyl, phenyl (optionally substituted by OH), mono- or bi-cyclic heteroaryl or 3-6C alkenyl (optionally substituted by phenyl); Q = (CHOR1)k-(CHOR2)l-(CHOR3)m-(CHOR4)n-CH2OR5 ; R1-R5 = H or lower alkanoyl, or two of R1-R5 = CO, CS or CH2 (optionally substituted by lower alkyl or 4-5C alkylene), completing a 5- or 6-membered ring; k, l, m, n = 0 or 1, and R6, R7 = H or halo. Independent claims are also included for: (1) the preparation of (I), and (2) new piperazine derivative intermediates of formula (II). |
申请公布号 |
DE50204379(D1) |
申请公布日期 |
2006.02.09 |
申请号 |
DE2002504379 |
申请日期 |
2002.09.07 |
申请人 |
SOLVAY PHARMACEUTICALS GMBH |
发明人 |
JASSERAND, DANIEL;PREUSCHOFF, ULF;ANTEL, JOCHEN;DAVID, SAMUEL;SANN, HOLGER;BRUECKNER, REINHARD;REICHE, DANIA;EECKHOUT, CHRISTIAN |
分类号 |
C07D295/12;A61K31/341;A61K31/381;A61K31/496;A61P1/00;A61P29/00;A61P43/00;C07D209/08;C07D295/08;C07D295/084;C07D295/092;C07D307/52;C07D333/20;C07D407/04;C07D407/06;C07D409/06 |
主分类号 |
C07D295/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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