DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH CHYMASE (CMA1)

摘要

The invention provides a human CMA1 which is associated with the cardiovascular diseases, infections, metabolic diseases, dermatological diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, metabolic diseases, dermatological diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CMA1 as well as pharmaceutical compositions comprising such compounds.