| 摘要 |
An adjuvant composition comprising first and second nucleic acid sequences is described to enhance an immune response against an antigen. The first nucleic acid sequence is a truncated A subunit coding region obtained or derived from a bacterial ADP-ribosylating exotoxin. The second nucleic acid sequence is a truncated B subunit coding region obtained or derived from a bacterial ADP-ribosylating exotoxin. The first and second nucleic acid sequences are operably linked to, or are each operably linked to, a promoter active in a mammalian cell. Use of the first and second nucleic acid is disclosed to be for the manufacture of a medicament for enhancing an immune response in a vertebrate subject against an antigen of interest. The antigen can be from a bacterial, viral or parasitic pathogen; and from the group consisting of an influenza virus, Herpes Simplex Virus (HSV) or a papilloma virus. A proviso explains that each of the truncated subunit coding regions has a 5' deletion and encodes a subunit peptide not having amino terminal bacterial signal peptide. A particle delivery device loaded with a particulate vaccine composition is also described.
|
