发明名称 |
Crystal structure of factor Vai and method for identifying blood factor Va modulators |
摘要 |
The present invention shows the crystal structure of protein C inactivated factor Va (A 1 -A 3 -C 1 -C 2 ) that depicts a novel domain arrangement. The newly disclosed orientation has implications for binding to membranes essential for function. A high-affinity calcium binding site and a copper binding site have been identified, neither of which show a direct involvement in chain association. This structure represents the largest physiologically relevant fragment of factor Va solved to date and provides a new scaffold for generation of models of coagulation factors.
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申请公布号 |
US2006014934(A1) |
申请公布日期 |
2006.01.19 |
申请号 |
US20050131091 |
申请日期 |
2005.05.17 |
申请人 |
EVERSE STEPHEN J;ADAMS TY E;HOCKIN MATTHEW F;MANN KENNETH G |
发明人 |
EVERSE STEPHEN J.;ADAMS TY E.;HOCKIN MATTHEW F.;MANN KENNETH G. |
分类号 |
C07K14/745;A61K38/48;G01N33/48 |
主分类号 |
C07K14/745 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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