The present invention relates to a chimeric chemokine receptor comprising two components: a first sequence comprising the N terminus through the last residue of the seven helix TM region of a first chemokine receptor joined with a second sequence comprising the C terminus of a second chemokine receptor extending from the first intracellular residue of the chemokine receptor to the last residue of the chemokine receptor. The chimeric chemokine receptor can be employed in various applications, such as ligand binding and screening assays and signalling assays. The chimeric chemokine receptor can also form a component of a chemokine receptor modulator design program.
申请公布号
WO2005049799(A3)
申请公布日期
2006.01.05
申请号
WO2004US37892
申请日期
2004.11.12
申请人
BRISTOL-MYERS SQUIBB COMPANY;DINCHUK, JOSEPH E.;DAVIES, PAUL;ZHAO, QIHONG;CARTER, PERCY, H.;SOLOMON, KIMBERLY, A.;SCHERLE, PEGGY ANN
发明人
DINCHUK, JOSEPH E.;DAVIES, PAUL;ZHAO, QIHONG;CARTER, PERCY, H.;SOLOMON, KIMBERLY, A.;SCHERLE, PEGGY ANN