摘要 |
The present invention relates to optionally substituted pyrido(2,3-d]- pyrimidine-2,4(1H,3H)-diones or optionally substituted pyrido[2,3-d]-pyrimidine-2(1H,3H)-ones, i.e., compounds of Formula (I) wherein: Y is -CH2- or -C(O)-; R1 is hydrogen or -(CH2)n; R7, wherein: R7 is aryl or heteroaryl, and n is 1 or 2, provided th at when Y is -C(O)-, R7 is heteroaryl; and R2, R3, R4, R5 and R6 are hydrogen, or one is selected from lower alkyl, halo, carboxy, methoxycarbonyl, carbamoyl, methylcarbamoyl, di-methylcarbamoyl, methylcarbonyl, methylthio, methylsulfinyl, methylsulfonyl, hydroxymethyl, amino, trifluoromethyl; cyano or nitro; or R2, R3, R4 and R5 are independently selected from hydrogen, lower alkyl, nitro, chloro, fluoro, methoxycarbonyl or methylcarbonyl, provided that at least one is hydrogen, a nd R6 is hydrogen; or a pharmaceutically acceptable ester, ether, N-oxide or salt thereof.
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