| 发明名称 |
PROCESS FOR PRODUCTION OF 2-CYANO-3-HYDROXY-N-(4-TRI- FLUOROMETHYLPHENYL)HEPT-2-EN-6-YNAMIDE AND PROCESS FOR PRODUCTION OF POLYMORPHS THEREOF |
| 摘要 |
<p>A compound (II) is reacted with a compound (III) or a reactive derivative at the carboxyl group thereof to obtain a compound (IV), which is reacted with a mixed acid anhydride of a compound (V) to prepare a compound (I). In recrystallization of the compound (I), temperature for the recrystallization and/or time for the crystal precipitation is controlled to selectively produce A-form crystals, B-form crystals and C-form crystals of the compound (I). ÄChemical formula 1Ü <CHEM> <CHEM> <CHEM></p> |
| 申请公布号 |
EP1609778(A1) |
申请公布日期 |
2005.12.28 |
| 申请号 |
EP20040722662 |
申请日期 |
2004.03.23 |
| 申请人 |
ASTELLAS PHARMA INC. |
发明人 |
OMORI, HIROKI;KUBOTA, ARIYOSHI;KAWAKAMI, TAKESHI;FUJII, YOSUKE;MATSUMOTO, IKUO;KITAYAMA, MASATO;GOTO, SHUNSUKE;HIRABAYASHI, SATOSHI |
| 分类号 |
C07C253/30;C07C253/34;C07C255/23;(IPC1-7):C07C255/23 |
主分类号 |
C07C253/30 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
