Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus

摘要

Described are synthetic peptides of at least 12 and at most 30 amino acid residues comprising a sequence consisting of, or found within, a complementarity-determining region (CDR) found in the heavy or light chain of the human anti-DNA 16/6Id monoclonal antibody, or a sequence obtained by replacement and/or deletion and/or addition of one or more amino residues to the sequence. Also, salts, chemical derivatives and polymers of the peptides, which can be used for immunomodulation of systemic lupus erythematosus-associated responses, are described...