Compositions and methods for modulating c-Rel-dependent cytokine production

摘要

The present invention is directed to compositions and methods for modulating c-Rel-dependent cytokine production without materially altering the level of expression of NFkappaB and/or the amount of IkappaB. The present invention is also directed to screening for modulators of c-Rel activity as determined by assaying for altered subcellular localization of c-Rel but where the level of expression of NFkappaB and/or the amount of IkappaB is materially unaltered.