摘要 |
The present invention relates to the compounds of the general formula I, N-oxide forms thereof, their pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein Re1 represents hydrogen, alkyl group containing 1 to 6 carbon atoms, alkyloxy group having 1 to 6 carbon atoms, alkylthio group containing 1 to 6 carbon atoms, amino group, mono- or dialkylamino group having 1 to 6 carbon atoms in the alkyl moiety, Are1, Are1-NH-, cycloalkyl containing 3 to 6 carbon atoms, hydroxymethyl or benzyloxymethyl; Re2 and Re3 denote hydrogen, or taken together may form a bivalent radical of the general formula -CH=CH-CH=CH-; Re4, Re5 and Re6 are each independently selected from hydrogen, a halogen, alkyl group containing 1 to 6 carbon atoms, alkyloxy group having 1 to 6 carbon atoms, trifluoromethyl, nitro group, amino group, cyano group, azido group, alkyloxyalkyl group containing 1 to 6 carbon atoms in both the alkyloxy and alkyl moieties, alkylthio group having 1 to 6 carbon atoms, alkyloxycarbonyl containing 1 to 6 carbon atoms or Hete1; or when Re4 and Re5 are adjacent to each other they may be taken together to form a radical of the general formula -CH=CH-CH=CH-; A represents a bivalent radical of the formula NRe7, NRe7-Alke1-X-, NRe7-Alke1-X-Alke2-, O-Alke1-X-, O-Alke1-X-Alke2-, or S-Alke1-X-; wherein X denotes a direct bond, -O-, -S-, C=O, -NRe8 or Hete2; Re7 stands for hydrogen, alkyl containing 1 to 6 carbon atoms or Are2methyl; Re8 represents hydrogen, alkyl containing 1 to 6 carbon atoms or Are2methyl; Alke1 denotes alkanediyl containing 1 to 6 carbon atoms in the alkane moiety; Alk2 represents alkanediyl having 1 to 4 carbon atoms in the alkane moiety; Are1 and Are2 represent optionally substituted phenyl; phenyl; Hete1 and Hete2 denote optionally substituted heterocycles; having angiogenesis inhibiting activity; and their preparation. The invention further relates to compositions containing them as well as their use as medicaments. |