MODULATION OF WRN-MEDIATED TELOMERE-INITIATED CELL SIGNALING
摘要
The use of modulators of WRN is described. Activators of WRN may be used to induce growth arrest, apoptosis or proliferative senescence, whereas inhibitors of WRN may be used to reduce growth arrest, apoptosis or prolifertative senescence. Methods of identifying modulators of WRN are also described.
申请公布号
WO2005113764(A2)
申请公布日期
2005.12.01
申请号
WO2005US17553
申请日期
2005.05.19
申请人
TRUSTEES OF BOSTON UNIVERSITY;GILCHREST, BARBARA, A.;ELLER, MARK, S.