DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR KINASE 4 (GRK4)

摘要

The invention provides a human GRK4 which is associated with cardiovascular diseases, endocrinological diseases, metabolic diseases, inflammation, hematological diseases, neurological diseases, urological diseases and respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, endocrinological diseases, metabolic diseases, inflammation, hematological diseases, neurological diseases, urological diseases and respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GRK4 as well as pharmaceutical compositions comprising such compounds.