| 摘要 |
Molecules that bind the CD80 (B7-1) ligand presented by Antigen Presenting Cells and thereby selectively inhibit costimulation of T cells. Various forms and preparations of these molecules may bind to the CD80 ligand under either or both in vivo or in vitro conditions. These molecules may be referred to as pseudo-receptors include polypeptides include polypeptides that incorporate the amino-acid sequence MQPPGC, and a retro-inverso peptide mimic that includes the D-amino acid sequence CGPPQM. These molecules have a propensity to adopt a polyproline type II helical conformation under physiological conditions. Uses for these molecules include studying the immune system, screening for other compounds that affect the immune system, or at least components of the immune system, and the treatment of autoimmune diseases such as multiple sclerosis, colitis (inflammatory bowel disease -IBD), rheumatoid arthritis, Crohn's disease, Sjorgren's syndrome, diabetes mellitus, and solid tissue transplant rejection. |
