摘要 |
<p>This invention relates to a method of treating drug side effects in cancer treatment. More particularly, the present invention relates to preventing, reducing, alleviating, or reversing diarrhea caused by the administration of the isothiazole 3-(4-Bromo-2,6-difluoro-benzyloxy)-5[3-(4-pyrrolidin-1-yl-butyl)-ureido]-isothiazole-4-carboxylic acid amide in the treatment of cancer comprising the step of administering to a patient in need of such treatment, prior to, simultaneously, or sequentially, a therapeutically effective amount of 3-(4-Bromo-2,6-difluoro benzyloxy)-5-[3-(4-pyrrolidin-1-yl-butyl)-ureido]-isothiazole-4-carboxylic acid amide or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of an antidiarrheal agent, a bulking agent, or an anti-estrogen. The combinations of the present invention may optionally include an anti-hypertensive agent.</p> |
申请人 |
PFIZER PRODUCTS INC.;HEALEY, DIANE, INGEBORG;BEEBE, JEAN;O'LEARY, JAMES, JOHN;ROBERTS, WALTER, GREGORY;TOLCHER, ANTHONY, WILLIAM;HUBERMAN, MARK, STEPHAN |
发明人 |
HEALEY, DIANE, INGEBORG;BEEBE, JEAN;O'LEARY, JAMES, JOHN;ROBERTS, WALTER, GREGORY;TOLCHER, ANTHONY, WILLIAM;HUBERMAN, MARK, STEPHAN |