| 发明名称 |
3,4-DISUBSTITUTED MALEIMIDES FOR USE AS VASCULAR DAMAGING AGENTS |
| 摘要 |
<p>This invention relates to novel compounds of Formula (I) for use as vascular damaging agents: Formula (I) wherein R<l>, R<7>, R<8>, R<9>, AR , AR<2>, AR<3>, p, q and r are as described in the specification. The invention also relates to methods for preparing compounds of Formula (I), to their use as medicaments (including methods for the treatment of angiogenesis or disease states associated with angiogenesis) and to pharmaceutical compositions containing compounds of Formula (I).</p> |
| 申请公布号 |
WO2005102997(A1) |
申请公布日期 |
2005.11.03 |
| 申请号 |
WO2005GB01553 |
申请日期 |
2005.04.22 |
| 申请人 |
ASTRAZENECA AB;ASTRAZENECA UK LIMITED;ARNOULD, JEAN-CLAUDE;HARRIS, CRAIG, STEVEN;BOYLE, FRANCIS, THOMAS;GIBSON, KEITH, HOPKINSON |
发明人 |
ARNOULD, JEAN-CLAUDE;HARRIS, CRAIG, STEVEN;BOYLE, FRANCIS, THOMAS;GIBSON, KEITH, HOPKINSON |
| 分类号 |
C07D207/44;C07D207/456;C07D401/04;C07D401/12;C07F9/09;C07F9/12;(IPC1-7):C07D207/44;A61K31/401;A61K31/661;A61P35/00 |
主分类号 |
C07D207/44 |
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